{"title":"Sleep \u0026 Cognitive","description":"","products":[{"product_id":"tesamorelin","title":"Tesamorelin","description":"\u003ch2\u003eWhat is Tesamorelin?\u003c\/h2\u003e\u003cp\u003eTesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), belonging to the class of peptide hormones. This bioactive compound consists of 44 amino acids and was originally developed by Theratechnologies Inc. in Canada. Tesamorelin distinguishes itself from natural GHRH by the addition of a trans-3-hexenoyl group at the N-terminus, which significantly improves its stability and half-life. The peptide was first synthesized in the early 2000s as part of research into growth hormone deficiency and metabolic disorders.\u003c\/p\u003e\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\u003cp\u003eTesamorelin exerts its biological effects by binding to the growth hormone-releasing hormone receptor (GHRHR) in the pituitary gland. This receptor, belonging to the class B G-protein coupled receptors, activates the cAMP-PKA signaling pathway upon binding with tesamorelin. This results in the stimulation of somatotropic cells, leading to increased synthesis and release of growth hormone (GH). The released growth hormone then binds to GH receptors in the liver, stimulating the production of insulin-like growth factor-1 (IGF-1). This cascade activates various anabolic processes, including protein synthesis, lipolysis in adipocytes, and gluconeogenesis in the liver. The hexenoyl group in tesamorelin prevents enzymatic degradation, allowing for more stable and prolonged GHRH receptor activation.\u003c\/p\u003e\u003ch2\u003eResearch Results\u003c\/h2\u003e\u003cp\u003ePreclinical studies have shown promising results for tesamorelin in various research models. In a randomized study with 412 participants, tesamorelin showed a significant reduction of 15.2% in visceral adipose tissue after 26 weeks of treatment, compared to an increase of 5.1% in the control group. Additionally, an average increase of 181% in IGF-1 levels was observed within 14 days of starting treatment. In animal models with rats, tesamorelin administration resulted in a 40% increase in growth hormone concentrations within 30 minutes of injection, with peak values lasting 3-4 hours. Studies on cognitive effects showed improvements in memory processes, with tesamorelin-treated mice performing 23% better in spatial memory tests compared to control groups. Research on body composition documented an average increase of 1.4 kg lean mass over a period of 6 months in research models.\u003c\/p\u003e\u003ch2\u003eAvailable Variants and Purity\u003c\/h2\u003e\u003cp\u003eDutch Peptide Labs offers tesamorelin in three research-friendly variants: 5mg (€99), 10mg (€159), and 20mg (€299). Each product comes with a guaranteed purity of at least 99.9%, verified by independent HPLC-MS analysis methods. Our tesamorelin is produced according to pharmaceutical GMP standards in certified European facilities. Each batch is accompanied by a Certificate of Analysis (CoA) confirming molecular identity, purity, and microbiological safety. The peptide is supplied in lyophilized form in sterile glass vials under a controlled atmosphere to prevent oxidation and degradation.\u003c\/p\u003e\u003ch2\u003eStorage and Handling\u003c\/h2\u003e\u003cp\u003eStore tesamorelin in lyophilized form at -20°C to -80°C, protected from light and moisture. Under these conditions, the peptide maintains its stability for at least 24 months. For reconstitution, sterile bacteriostatic water or physiological saline solution is recommended at a ratio of 1-2ml per 5mg of peptide. After reconstitution, the solution should be stored refrigerated at 2-8°C and used within 14 days for optimal activity. Avoid repeated freezing and thawing, as this can compromise molecular integrity. Always use sterile techniques when handling and ensure adequate personal protective equipment during laboratory work.\u003c\/p\u003e\u003ch2\u003eResearch Disclaimer\u003c\/h2\u003e\u003cp\u003eThis product is intended solely for scientific research and in vitro applications. Tesamorelin is not approved for human consumption, therapeutic treatment, or veterinary purposes. Dutch Peptide Labs supplies this peptide only to qualified research institutions, universities, and authorized scientists for legitimate research purposes. The buyer declares and guarantees that the product will be used in accordance with all applicable laws and regulations. We accept no responsibility for misuse, improper application, or unintended effects arising from the use of this research product.\u003c\/p\u003e","brand":"Dutch Peptide Labs","offers":[{"title":"10mg","offer_id":56323917218118,"sku":"TSM-10mg","price":64.95,"currency_code":"EUR","in_stock":true},{"title":"20mg","offer_id":56323917250886,"sku":"TSM-20mg","price":119.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/7055\/6998\/files\/tesamorelin-5mg.png?v=1775543739"},{"product_id":"dsip","title":"DSIP","description":"\u003ch2\u003eWhat is DSIP?\u003c\/h2\u003e\u003cp\u003eDelta Sleep-Inducing Peptide (DSIP) is a neuropeptide consisting of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. This unique peptide was first isolated in 1977 from the brains of rabbits by Schoenenberger and Monnier during their research into sleep-regulating factors. DSIP belongs to the class of endogenous sleep-modulating peptides and is naturally produced in the hypothalamus and other brain regions. The molecular formula of DSIP is C35H48N10O15 with a molecular weight of 848.81 Da. This cyclic peptide is characterized by its stable structure and unique pharmacological properties.\u003c\/p\u003e\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\u003cp\u003eThe mechanism of action of DSIP is complex and affects multiple neurotransmitter systems in the central nervous system. DSIP modulates the activity of GABAergic neurons in the hypothalamus and interacts with various neurotransmitter receptors, including dopamine, serotonin, and GABA receptors. The peptide influences circadian rhythms by regulating melatonin production in the pineal gland and modulates the hypothalamic-pituitary-adrenal (HPA) axis. DSIP also exhibits antioxidant properties by scavenging free radicals and protecting neuronal cells from oxidative stress. Additionally, the peptide regulates the expression of various growth factors and cytokines involved in neuroprotection and neuronal plasticity.\u003c\/p\u003e\u003ch2\u003eResearch Results\u003c\/h2\u003e\u003cp\u003ePreclinical studies have shown promising results for DSIP's neuroprotective and sleep-modulating properties. In a study with rats (Graf et al., 1982), DSIP administration increased slow-wave sleep by 40% and significantly improved sleep quality. Research by Kastin et al. (1984) showed that DSIP reduced the stress response by 60% reduction in cortisol levels in chronic stress. Cellular studies by Bonnet et al. (1995) demonstrated that DSIP protected neuronal cells against glutamate-induced excitotoxicity with a survival rate of 85% versus 45% in control groups. More recent studies (Nishino et al., 2000) have shown that DSIP increases the production of BDNF (Brain-Derived Neurotrophic Factor) by 150% in hippocampal neurons, suggesting that the peptide may promote neuroplasticity and memory formation.\u003c\/p\u003e\u003ch2\u003eAvailable variants and purity\u003c\/h2\u003e\u003cp\u003eDutch Peptide Labs offers DSIP in two variants: 5mg (€49) and 10mg (€75). Our DSIP is produced according to the highest quality standards with a guaranteed purity of 99.9%, verified by independent laboratories through HPLC and mass spectrometry analyses. Each batch is provided with a Certificate of Analysis (CoA) confirming the exact purity, identity, and strength. The peptide is supplied as lyophilized white powder in sterile glass vials under an inert atmosphere to ensure maximum stability.\u003c\/p\u003e\u003ch2\u003eStorage and handling\u003c\/h2\u003e\u003cp\u003eDSIP should be stored at temperatures between -20°C to -80°C in the original packaging, protected from light and moisture. In lyophilized form, the peptide is stable for at least 24 months under these conditions. For reconstitution, sterile bacteriostatic water or physiological saline solution is recommended. After reconstitution, the solution should be used within 48 hours when stored at 2-8°C, or can be frozen in aliquots at -20°C for longer storage up to 6 months. Avoid repeated freeze-thaw cycles to prevent peptide degradation.\u003c\/p\u003e\u003ch2\u003eResearch disclaimer\u003c\/h2\u003e\u003cp\u003eThis product is intended solely for scientific research and in vitro applications. DSIP is not approved for human consumption, medical treatment, or diagnostic purposes. Users must observe all relevant safety protocols and handle the product exclusively in authorized research facilities. Dutch Peptide Labs is not responsible for misuse of this product outside of scientific research purposes.\u003c\/p\u003e","brand":"Dutch Peptide Labs","offers":[{"title":"5 mg","offer_id":56323917742406,"sku":"DS-5mg","price":49.0,"currency_code":"EUR","in_stock":true},{"title":"10mg","offer_id":56323917775174,"sku":"DS-10mg","price":75.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/7055\/6998\/files\/dsip-5mg_1406461f-3a23-4875-9652-48698724c43a.png?v=1775543767"},{"product_id":"nad-plus","title":"NAD+","description":"\u003ch2\u003eWhat is NAD+?\u003c\/h2\u003e\u003cp\u003eNicotinamide adenine dinucleotide (NAD+) is an essential cofactor found in all living cells and belongs to the class of nucleotide cofactors. This dinucleotide consists of two nucleoside molecules linked by their phosphate groups, comprising nicotinamide riboside and adenosine. NAD+ was first discovered in 1906 by British biochemists Arthur Harden and William John Young during their research into alcoholic fermentation in yeast cells. The molecule plays a crucial role as an electron acceptor in redox reactions and is fundamental for cellular energy production.\u003c\/p\u003e\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\u003cp\u003eNAD+ functions as a critical cofactor for over 400 enzymatic reactions in the human body. The molecule primarily acts via three main pathways: as a cofactor for dehydrogenases in glycolysis and the citric acid cycle, as a substrate for sirtuins (SIRT1-7) involved in gene expression and DNA repair, and as a substrate for poly(ADP-ribose) polymerases (PARPs) that detect and repair DNA damage. NAD+ accepts electrons and is reduced to NADH, generating energy for ATP synthesis. Additionally, NAD+ activates sirtuin proteins by cleaving off NAM (nicotinamide), resulting in deacetylation of histones and transcription factors, leading to improved mitochondrial biogenesis and cellular stress resistance.\u003c\/p\u003e\u003ch2\u003eResearch Results\u003c\/h2\u003e\u003cp\u003ePreclinical studies have shown promising results for NAD+ supplementation. A landmark study published in Cell (2016) by Yoshino et al. demonstrated that NAD+ precursors increased the lifespan of mice by 10-15% and improved mitochondrial function. In C. elegans models, NAD+ supplementation resulted in a 25% extension of lifespan (Mouchiroud et al., Nature 2013). Cell culture studies show that increased NAD+ levels enhance SIRT1 activity by 40-60%, leading to improved DNA repair and reduced oxidative stress markers. Research on yeast cells showed a 30% improvement in mitochondrial respiration and ATP production when treated with NAD+ precursors (Belenky et al., Cell 2007).\u003c\/p\u003e\u003ch2\u003eAvailable Variants and Purity\u003c\/h2\u003e\u003cp\u003eOur NAD+ is available in two research variants: 500mg (€65) and 1000mg (€119), both produced according to pharmaceutical GMP standards. The product has a guaranteed purity of ≥99.9% as verified by high-resolution LC-MS\/MS analysis. Each batch is independently tested by a certified analytical laboratory for purity, identity, and microbiological contaminants. A Certificate of Analysis (CoA) is provided with every order, detailing specifications and test results.\u003c\/p\u003e\u003ch2\u003eStorage and Handling\u003c\/h2\u003e\u003cp\u003eStore NAD+ powder at -20°C in the original sealed container, protected from light and moisture. Under these conditions, the product retains its stability for at least 24 months. For reconstitution, sterile water or phosphate-buffered saline (PBS, pH 7.4) is recommended. Reconstituted solutions should be used within 48 hours when stored at 4°C, or can be frozen at -80°C for long-term storage up to 6 months. Avoid repeated freeze-thaw cycles to prevent degradation.\u003c\/p\u003e\u003ch2\u003eResearch Disclaimer\u003c\/h2\u003e\u003cp\u003eThis NAD+ product is intended for in vitro scientific research by qualified researchers and laboratories only. It is not approved for human consumption, therapeutic application, or diagnostic purposes. Users are responsible for complying with local regulations regarding the handling of research chemicals. Dutch Peptide Labs disclaims all responsibility for misuse of this product outside scientific research contexts.\u003c\/p\u003e","brand":"Dutch Peptide Labs","offers":[{"title":"500mg","offer_id":56323918070086,"sku":"NJ-500mg","price":68.95,"currency_code":"EUR","in_stock":true},{"title":"1000mg","offer_id":56323918102854,"sku":"NJ-1000mg","price":119.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/7055\/6998\/files\/nad-500mg.png?v=1775578774"},{"product_id":"semax","title":"Semax","description":"","brand":"Dutch Peptide Labs","offers":[{"title":"10mg","offer_id":57263153873222,"sku":null,"price":34.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/7055\/6998\/files\/Now_change_it_to_Semax_2K_202609061936.jpg?v=1788716218"},{"product_id":"selank","title":"Selank","description":"","brand":"Dutch Peptide Labs","offers":[{"title":"10mg","offer_id":57263168061766,"sku":null,"price":29.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/7055\/6998\/files\/Change_MOTS-c_to_Selank_2K_202609061936.jpg?v=1788716179"}],"url":"https:\/\/dutchpeptidelabs.nl\/en\/collections\/sleep-cognition.oembed","provider":"Dutch Peptide Labs","version":"1.0","type":"link"}