MOTS-c

What is MOTS-c?

MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino acid peptide that was described in 2015 by the research group of Lee and colleagues in Cell Metabolism. It differs from most research peptides in that it is not encoded in nuclear DNA, but in the mitochondrial genome—specifically in the 12S rRNA region. MOTS-c thus belongs to the mitochondrially derived peptides (MDPs), a class of signaling molecules that mediate communication between the mitochondrion and the rest of the cell. The amino acid sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR).

Analysis and identity

Every batch is tested independently by an external laboratory. The certificate of analysis for this product is available on this page and states the method used, the purity determined and the date of analysis.

Available variants

MOTS-c is available in 10mg and 20mg. The current price for each is shown with the product options on this page.

Storage and handling

Store at -20 °C, dry and dark. After reconstitution, store at 2–8 °C and use within 2–4 weeks.

Research disclaimer

MOTS-c supplied by Dutch Peptide Labs is intended solely for in vitro laboratory research and scientific purposes. This product is not intended for human or animal consumption, medicinal use, dietary application or therapeutic injection, and has not been approved by regulatory agencies such as the EMA or the FDA. Dutch Peptide Labs makes no claims as to effect, suitability or safety for any application in humans or animals. All use must take place under the supervision of qualified researchers. The seller accepts no liability for unauthorised or unlawful use of this product.